国际眼科纵览 ›› 2023, Vol. 47 ›› Issue (3): 276-282.doi: 10.3760/ cma.j.issn.1673-5803.2023.03.014

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网状黄斑病变与系统性微循环障碍的关系

褚哲1  任奇1  程璐2  程浩3   

  1. 1山东第一医科大学附属眼科研究所 山东第一医科大学附属青岛眼科医院 山东省眼科学重点实验室-省部共建国家重点实验室培育基地 山东第一医科大学眼科学院,青岛 266071;2中山大学中山眼科中心 眼科学国家重点实验室,广州 510060;3广州医科大学附属第一医院眼科 510120

  • 收稿日期:2022-10-08 出版日期:2023-06-22 发布日期:2023-06-29
  • 通讯作者: 程浩,Email: chrischenghao@gzhmu.edu.cn
  • 基金资助:
    广州市科技计划项目(202201020458)

Relationship between reticular macular disease and systemic microvascular dysfunction

Chu Zhe1, Ren Qi1, Cheng Lu2, Cheng Hao3   

  1. 1Eye Institute of Shandong First Medical University, Qingdao Eye Hospital of Shandong First Medical University, State Key Laboratory Cultivation Base, Shandong Provincial Key Laboratory of Ophthalmology, School of Ophthalmology, Shandong First Medical University, Qingdao 266071, China; 2Zhongshan Ophthalmic Centre, Sun Yat-sen University, State Key Laboratory of Ophthalmology, Guangzhou 510060, China; 3Department of Ophthalmology, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China
  • Received:2022-10-08 Online:2023-06-22 Published:2023-06-29
  • Contact: Cheng Hao, Email: chrischenghao@gzhmu.edu.cn
  • Supported by:
    Science and Technology Program of Guangzhou(202201020458)

摘要: 网状黄斑病变(reticular macular disease,RMD)是早中期年龄相关性黄斑变性的一种重要表型,与脉络膜毛细血管层灌注障碍即微循环障碍密切相关。微循环功能障碍可导致组织功能障碍,特别是对于眼、肾、心等高代谢器官尤为明显。多项研究提示了RMD可能是与其他器官(如肾脏和心脏)毛细血管床功能障碍相关的多系统疾病的一部分。肾脏、心脏等器官的微循环障碍与RMD的发生相关,在发病机制上它们存在着内在关联,RMD或许可作为慢性肾病、冠状动脉疾病或冠状动脉微循环障碍等疾病发生的预测指标。(国际眼科纵览,2023, 47:276-282

关键词: 网状黄斑病变, 年龄相关性黄斑变性, 微循环障碍, 慢性肾病, 冠状动脉疾病

Abstract: Reticular macular disease (RMD) is an important phenotype of early and intermediate-stage age-related macular degeneration, which is closely related to choroidal capillary layer perfusion disorders, i.e., microcirculation disorders. Microcirculation dysfunction can lead to tissue dysfunction, especially for the eyes, kidney, heart and other hypermetabolic organs. Several studies indicate RMD may be part of a multisystem disorder affecting other vascular beds such as the kidney and heart. Microcirculatory disorders in kidney, heart and other organs are related to the occurrence of RMD, and they are intrinsically related in their pathogenesis. RMD may be used as a predictor of chronic kidney disease, coronary artery disease or coronary artery microcirculation disorders. (Int Rev Ophthalmol, 2023, 47: 276-282)

Key words: reticular macular disease, age-related macular degeneration, microcirculation disorders, chronic kidney disease, coronary artery disease